TARGETID

T14592

FORMERID

TTDI02199

UNIPROID

TNR6_HUMAN

TARGNAME

Apoptosis mediating surface antigen FAS (FAS)

GENENAME

FAS

TARGTYPE

Clinical trial target

SYNONYMS

Tumor necrosis factor receptor superfamily member 6; TNFRSF6; FASLG receptor; FAS1; CD95; Apoptosis-mediating surface antigen FAS; Apo-1 antigen; APT1

FUNCTION

The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Receptor for TNFSF6/FASLG.

PDBSTRUC

3TJE; 3THM; 3EZQ; 3EWT; 2NA7

BIOCLASS

Cytokine receptor

SEQUENCE

MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV

DRUGINFO

VB-111

DRUGINFO

APG-101

DRUGINFO

DE-098

DRUGINFO

APO-010

DRUGINFO

2-aminophenoxazine-3-one

DRUGINFO

APG-103

DRUGINFO

F61F12

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction