TARGETID

T14143

FORMERID

TTDC00272

UNIPROID

TGFB2_HUMAN

TARGNAME

Transforming growth factor beta 2 (TGFB2)

GENENAME

TGFB2

TARGTYPE

Clinical trial target

SYNONYMS

Transforming growth factor beta-2 proprotein; TGF-beta 2; Polyergin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Cetermin; BSC-1 cell growth inhibitor

FUNCTION

Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.

PDBSTRUC

5TY4; 5TX4; 4KXZ; 2TGI; 1TFG

BIOCLASS

Growth factor

SEQUENCE

MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS

DRUGINFO

AP12009

DRUGINFO

Lerdelimumab

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04068:FoxO signaling pathway

KEGGPATH

hsa04110:Cell cycle

KEGGPATH

hsa04144:Endocytosis

KEGGPATH

hsa04350:TGF-beta signaling pathway

KEGGPATH

hsa04380:Osteoclast differentiation