TARGETID

T12355

FORMERID

TTDR00397

UNIPROID

CCND1_HUMAN

TARGNAME

G1/S-specific cyclin-D1 (CCND1)

GENENAME

CCND1

TARGTYPE

Clinical trial target

SYNONYMS

PRAD1 oncogene; PRAD1; Cyclin D1; BCL1; BCL-1 oncogene; BCL-1; B-cell lymphoma 1 protein

FUNCTION

Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition.

PDBSTRUC

5VZU; 2W9Z; 2W9F; 2W99; 2W96

SEQUENCE

MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI

DRUGINFO

ABT-263

DRUGINFO

Briciclib

DRUGINFO

3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione

DRUGINFO

3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione

DRUGINFO

3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione

DRUGINFO

3,4-diphenyl-1H-pyrrole-2,5-dione

DRUGINFO

4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol

DRUGINFO

7-hydroxycoumarin

KEGGPATH

hsa04068:FoxO signaling pathway

KEGGPATH

hsa04110:Cell cycle