靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T11487

FORMERID

TTDC00313

UNIPROID

THIL_HUMAN

TARGNAME

Acetoacetyl-CoA thiolase (ACAT1)

GENENAME

ACAT1

TARGTYPE

Clinical trial target

SYNONYMS

T2; MAT; Acetyl-CoA acetyltransferase, mitochondrial

FUNCTION

Plays a major role in ketone body metabolism.

PDBSTRUC

2IBY; 2IBW; 2IBU; 2IB9; 2IB8

BIOCLASS

Acyltransferase

ECNUMBER

EC 2.3.1.9

SEQUENCE

MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGASAMLIQKL

DRUGINFO

D0LM4U

ATR-01

Phase 1

DRUGINFO

D04TSP

PMID25470667-Compound-K-604

Patented

DRUGINFO

D00CCI

Benoxaprofen

Withdrawn from market

DRUGINFO

D0T9RD

(Z)-2,6-diisopropyl-N-phenyloctadec-9-enamide

Investigative

DRUGINFO

D07LER

Nonanoic acid biphenyl-2-ylamide

Investigative

DRUGINFO

D0A7YE

Octanoic acid biphenyl-2-ylamide

DRUGINFO

PMID16242323C15a

DRUGINFO

PMID16242323C15b

目标的 KEGG 通路数据

标题	内容
hsa00071	Fatty acid degradation
hsa00072	Synthesis and degradation of ketone bodies
hsa00280	Valine, leucine and isoleucine degradation
hsa00310	Lysine degradation
hsa00380	Tryptophan metabolism
hsa00620	Pyruvate metabolism
hsa00630	Glyoxylate and dicarboxylate metabolism
hsa00640	Propanoate metabolism
hsa00650	Butanoate metabolism
hsa00900	Terpenoid backbone biosynthesis
hsa01100	Metabolic pathways
hsa01130	Biosynthesis of antibiotics
hsa01200	Carbon metabolism
hsa01212	Fatty acid metabolism

目标的 Wiki 路径数据

标题	内容
WP465	Tryptophan metabolism
WP311	Synthesis and Degradation of Ketone Bodies
WP2693	Metabolism of amino acids and derivatives
WP1817	Fatty acid, triacylglycerol, and ketone body metabolism
WP143	Fatty Acid Beta Oxidation

目标的蛋白质ID

标题	内容
TARGETID	T11487
UNIPROID	THIL_HUMAN
TARGNAME	Acetoacetyl-CoA thiolase (ACAT1)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Acetoacetyl-CoA thiolase (ACAT1)	MAVLAALLRSGARSRSPLLRRLVQEIRYVERSYVSKPTLKEVVIVSATRTPIGSFLGSLSLLPATKLGSIAIQGAIEKAGIPKEEVKEAYMGNVLQGGEGQAPTRQAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMNRGSTPYGGVKLEDLIVKDGLTDVYNKIHMGSCAENTAKKLNIARNEQDAYAINSYTRSKAAWEAGKFGNEVIPVTVTVKGQPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAALVLMTADAAKRLNVTPLARIVAFADAAVEPIDFPIAPVYAASMVLKDVGLKKEDIAMWEVNEAFSLVVLANIKMLEIDPQKVNINGGAVSLGHPIGMSGARIVGHLTHALKQGEYGLASICNGGGGASAMLIQKL

标题

内容

Acetoacetyl-CoA thiolase (ACAT1)

最新招商产品更多>>