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靶点信息91(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cathepsin K (CTSK)
TARGTYPE
Clinical trial target
SYNONYMS
Cathepsin X; Cathepsin O2; Cathepsin O; CTSO2; CTSO
FUNCTION
Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling.
PDBSTRUC
7PCK; 6QBS; 6ASH; 5Z5O; 5TUN
SEQUENCE
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
DRUGINFO
Oxotetrahydro-2-H-furo[3.2-b]pyrrol-4(5-H)-yl derivative 1
DRUGINFO
PMID25399719-Compound-17
DRUGINFO
PMID27998201-Compound-10
DRUGINFO
PMID27998201-Compound-12
DRUGINFO
PMID27998201-Compound-15
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04142 |
|
| hsa04380 |
|
| hsa04620 |
|
| hsa05323 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|