TARGETID

T11309

FORMERID

TTDR00451

UNIPROID

CCL2_HUMAN

TARGNAME

Monocyte chemotactic and activating factor (CCL2)

GENENAME

CCL2

TARGTYPE

Clinical trial target

SYNONYMS

Small-inducible cytokine A2; SCYA2; Monocyte secretory protein JE; Monocyte chemotactic protein 1; Monocyte chemoattractant protein-1; Monocyte Chemoattractant Protein 1; MCP1; MCP-1; MCAF; HC11; C-C motif chemokine 2

FUNCTION

Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Acts as a ligand for C-C chemokine receptor CCR2.

PDBSTRUC

4ZK9; 4R8I; 4DN4; 3IFD; 2NZ1

BIOCLASS

Cytokine: CC chemokine

SEQUENCE

MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT

DRUGINFO

Bindarit

DRUGINFO

Carlumab

DRUGINFO

NOX-E36

DRUGINFO

CNTO888

DRUGINFO

ABN-912

DRUGINFO

MCP-1

DRUGINFO

RS-504393

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04062:Chemokine signaling pathway