靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T10670

FORMERID

TTDC00040

UNIPROID

NPY2R_HUMAN

TARGNAME

Neuropeptide Y receptor type 2 (NPY2R)

GENENAME

NPY2R

TARGTYPE

Clinical trial target

SYNONYMS

Y2 receptor; NPY2R; NPY2-R; NPY-Y2 receptor

FUNCTION

Receptor for neuropeptide Y andpeptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

PDBSTRUC

2IK3

BIOCLASS

GPCR rhodopsin

SEQUENCE

MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV

DRUGINFO

D0I1KQ

NEUROPEPTIDE-Y

Phase 2

DRUGINFO

D0S2LQ

PYY3-36

Discontinued in Phase 2

DRUGINFO

D07SWU

TM30338

Discontinued in Phase 2

DRUGINFO

D03WMK

AC-162352

Discontinued in Phase 1

DRUGINFO

BMS-192548

DRUGINFO

AcNPY(25-36)

DRUGINFO

AcPYY(22-36)

DRUGINFO

AcPYY(25-36)

DRUGINFO

AcPYY(26-36)

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction

目标的 Wiki 路径数据

标题	内容
WP455	GPCRs, Class A Rhodopsin-like
WP24	Peptide GPCRs
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T10670
UNIPROID	NPY2R_HUMAN
TARGNAME	Neuropeptide Y receptor type 2 (NPY2R)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Neuropeptide Y receptor type 2 (NPY2R)	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV

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