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靶点信息50(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
T-cell surface glycoprotein CD4 (CD4)
TARGTYPE
Successful target
SYNONYMS
T-cell surface antigen T4/Leu-3
FUNCTION
In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
PDBSTRUC
6MET; 6MEO; 6EDU; 6CM3; 5VN3
SEQUENCE
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
DRUGINFO
Fluoropeptide vaccine
目标的 KEGG 通路数据
标题 | 内容 |
hsa04514 |
|
hsa04612 |
|
hsa04640 |
|
hsa04660 |
|
hsa05340 |
|
目标的 Wiki 路径数据
标题 | 内容 |
WP69 |
|
WP530 |
|
WP2684 |
|
WP2671 |
|
WP2658 |
|
WP1927 |
|
WP1799 |
|
目标的蛋白质ID
标题 | 内容 |
TARGETID |
|
UNIPROID |
|
TARGNAME |
|
TARGTYPE |
|
目标的序列数据
标题 | 内容 |
T-cell surface glycoprotein CD4 (CD4) |
|