靶点信息50(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T10191
FORMERID
TTDC00265
UNIPROID
CD4_HUMAN
TARGNAME
T-cell surface glycoprotein CD4 (CD4)
GENENAME
CD4
TARGTYPE
Successful target
SYNONYMS
T-cell surface antigen T4/Leu-3
FUNCTION
In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses.
PDBSTRUC
6MET; 6MEO; 6EDU; 6CM3; 5VN3
BIOCLASS
Immunoglobulin
SEQUENCE
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
DRUGINFO
Ibalizumab
DRUGINFO
Magrolimab
DRUGINFO
TNX-355
DRUGINFO
Zanolimumab
DRUGINFO
BT-061
DRUGINFO
Fluoropeptide vaccine
DRUGINFO
CD4CAR
DRUGINFO
Combinectin
DRUGINFO
LIPO-4
目标的 KEGG 通路数据
标题内容
hsa04514
hsa04612
hsa04640
hsa04660
hsa05340
目标的 Wiki 路径数据
标题内容
WP69
WP530
WP2684
WP2671
WP2658
WP1927
WP1799
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
T-cell surface glycoprotein CD4 (CD4)
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