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靶点信息32(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Follicle stimulating hormone (FSHB)
TARGTYPE
Clinical trial target
SYNONYMS
Follitropin subunit beta; Follitropin beta chain; Follicle-stimulating hormone beta subunit; FSH-beta; FSH-B
FUNCTION
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs.
PDBSTRUC
4MQW; 4AY9; 1XWD; 1FL7
SEQUENCE
MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE
DRUGINFO
Follicle stimulating hormone
KEGGPATH
hsa04080:Neuroactive ligand-receptor interaction
KEGGPATH
hsa04912:GnRH signaling pathway
KEGGPATH
hsa04913:Ovarian steroidogenesis
KEGGPATH
hsa04917:Prolactin signaling pathway
KEGGPATH
hsa04918:Thyroid hormone synthesis
KEGGPATH
hsa05320:Autoimmune thyroid disease
WIKIPATH
WP1824:GPCR downstream signaling
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04080 |
|
| hsa04912 |
|
| hsa04913 |
|
| hsa04917 |
|
| hsa04918 |
|
| hsa05320 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2749 |
|
| WP2693 |
|
| WP2691 |
|
| WP2035 |
|
| WP2032 |
|
| WP1981 |
|
| WP1825 |
|
| WP1824 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Follicle stimulating hormone (FSHB) |
|