TARGETID

T10091

FORMERID

TTDR00221

UNIPROID

OPSD_HUMAN

TARGNAME

Rhodopsin (RHO)

GENENAME

RHO

TARGTYPE

Literature-reported target

SYNONYMS

Opsin-2; OPN2

FUNCTION

Required for photoreceptor cell viability after birth. Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Photoreceptor required for image-forming vision at low light intensity.

PDBSTRUC

6CMO; 5W0P; 5DGY; 4ZWJ

BIOCLASS

GPCR rhodopsin

SEQUENCE

MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA

DRUGINFO

(Hydroxyethyloxy)Tri(Ethyloxy)Octane

DRUGINFO

Alpha-D-Mannose

DRUGINFO

B-2-Octylglucoside

DRUGINFO

Beta-D-Mannose

DRUGINFO

B-Nonylglucoside

DRUGINFO

B-Octylglucoside

DRUGINFO

Heptane-1,2,3-Triol

DRUGINFO

Heptyl 1-Thiohexopyranoside

DRUGINFO

Hexadecanal