靶点信息23(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T09423
FORMERID
TTDS00431
UNIPROID
KCJ10_HUMAN
TARGNAME
Inward rectifier potassium channel Kir1.2 (KCNJ10)
GENENAME
KCNJ10
TARGTYPE
Successful target
SYNONYMS
Potassiumchannel, inwardly rectifying, subfamily J, member 10; Potassium channel, inwardly rectifying subfamily J member 10; Inward rectifier K+ channel Kir1.2; Inward rectifier K(+) channel Kir1.2; ATP-sensitive inward rectifier potassium channel 10; ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP dependent K+ channel
FUNCTION
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. May be responsible for potassium buffering action of glial cells in the brain.
BIOCLASS
Inward rectifier potassium channel
SEQUENCE
MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
DRUGINFO
Chlorpropamide
DRUGINFO
Glipizide
DRUGINFO
Gliquidone
DRUGINFO
Glisoxepide
DRUGINFO
Glycodiazine
DRUGINFO
Mitiglinide
DRUGINFO
Tolazamide
DRUGINFO
Sulfonylthioureas
KEGGPATH
hsa04971:Gastric acid secretion
WIKIPATH
WP2669:Potassium Channels
目标的 KEGG 通路数据
标题内容
hsa04971
目标的 Wiki 路径数据
标题内容
WP2754
WP2669
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Inward rectifier potassium channel Kir1.2 (KCNJ10)
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