TARGETID

T09423

FORMERID

TTDS00431

UNIPROID

KCJ10_HUMAN

TARGNAME

Inward rectifier potassium channel Kir1.2 (KCNJ10)

GENENAME

KCNJ10

TARGTYPE

Successful target

SYNONYMS

Potassiumchannel, inwardly rectifying, subfamily J, member 10; Potassium channel, inwardly rectifying subfamily J member 10; Inward rectifier K+ channel Kir1.2; Inward rectifier K(+) channel Kir1.2; ATP-sensitive inward rectifier potassium channel 10; ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP dependent K+ channel

FUNCTION

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. May be responsible for potassium buffering action of glial cells in the brain.

BIOCLASS

Inward rectifier potassium channel

SEQUENCE

MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV

DRUGINFO

Chlorpropamide

DRUGINFO

Glipizide

DRUGINFO

Gliquidone

DRUGINFO

Glisoxepide

DRUGINFO

Glycodiazine

DRUGINFO

Mitiglinide

DRUGINFO

Tolazamide

DRUGINFO

Sulfonylthioureas

KEGGPATH

hsa04971:Gastric acid secretion

WIKIPATH

WP2669:Potassium Channels