TARGETID

T09092

FORMERID

TTDR00138

UNIPROID

IL10_HUMAN

TARGNAME

Interleukin-10 (IL10)

GENENAME

IL10

TARGTYPE

Clinical trial target

SYNONYMS

IL-10; Cytokine synthesis inhibitory factor; CSIF

FUNCTION

Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.

PDBSTRUC

2ILK; 2H24; 1Y6K; 1LK3; 1J7V

BIOCLASS

Cytokine: interleukin

SEQUENCE

MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN

DRUGINFO

AM0010

DRUGINFO

F-8-IL-10 fusion protein

DRUGINFO

Ilodecakin

DRUGINFO

AG019

DRUGINFO

Ankinara

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04068:FoxO signaling pathway

KEGGPATH

hsa04630:Jak-STAT signaling pathway

KEGGPATH

hsa04660:T cell receptor signaling pathway