靶点信息47(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T09092
FORMERID
TTDR00138
UNIPROID
IL10_HUMAN
TARGNAME
Interleukin-10 (IL10)
GENENAME
IL10
TARGTYPE
Clinical trial target
SYNONYMS
IL-10; Cytokine synthesis inhibitory factor; CSIF
FUNCTION
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
PDBSTRUC
2ILK; 2H24; 1Y6K; 1LK3; 1J7V
BIOCLASS
Cytokine: interleukin
SEQUENCE
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
DRUGINFO
AM0010
DRUGINFO
F-8-IL-10 fusion protein
DRUGINFO
Ilodecakin
DRUGINFO
AG019
DRUGINFO
Ankinara
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04068:FoxO signaling pathway
KEGGPATH
hsa04630:Jak-STAT signaling pathway
KEGGPATH
hsa04660:T cell receptor signaling pathway
目标的 KEGG 通路数据
标题内容
hsa04060
hsa04068
hsa04630
hsa04660
hsa04672
hsa05133
hsa05140
hsa05142
hsa05143
hsa05144
hsa05145
hsa05146
hsa05150
hsa05152
hsa05169
hsa05310
hsa05320
hsa05321
hsa05322
hsa05330
目标的 Wiki 路径数据
标题内容
WP706
WP530
WP2328
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Interleukin-10 (IL10)
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