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靶点信息47(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Interleukin-10 (IL10)
TARGTYPE
Clinical trial target
SYNONYMS
IL-10; Cytokine synthesis inhibitory factor; CSIF
FUNCTION
Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation. In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
PDBSTRUC
2ILK; 2H24; 1Y6K; 1LK3; 1J7V
BIOCLASS
Cytokine: interleukin
SEQUENCE
MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN
DRUGINFO
F-8-IL-10 fusion protein
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04068:FoxO signaling pathway
KEGGPATH
hsa04630:Jak-STAT signaling pathway
KEGGPATH
hsa04660:T cell receptor signaling pathway
目标的 KEGG 通路数据
标题 | 内容 |
hsa04060 |
|
hsa04068 |
|
hsa04630 |
|
hsa04660 |
|
hsa04672 |
|
hsa05133 |
|
hsa05140 |
|
hsa05142 |
|
hsa05143 |
|
hsa05144 |
|
hsa05145 |
|
hsa05146 |
|
hsa05150 |
|
hsa05152 |
|
hsa05169 |
|
hsa05310 |
|
hsa05320 |
|
hsa05321 |
|
hsa05322 |
|
hsa05330 |
|
目标的蛋白质ID
标题 | 内容 |
TARGETID |
|
UNIPROID |
|
TARGNAME |
|
TARGTYPE |
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目标的序列数据
标题 | 内容 |
Interleukin-10 (IL10) |
|