TARGETID

T08910

FORMERID

TTDS00428

UNIPROID

GBRG2_HUMAN

TARGNAME

GABA(A) receptor gamma-2 (GABRG2)

GENENAME

GABRG2

TARGTYPE

Successful target

SYNONYMS

Gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2

FUNCTION

Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain.

PDBSTRUC

6I53; 6HUP; 6HUO; 6HUK; 6HUJ

BIOCLASS

Neurotransmitter receptor

SEQUENCE

MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

DRUGINFO

Allopregnanolone

DRUGINFO

THIOCOLCHICOSIDE

DRUGINFO

ZK-93423

DRUGINFO

GSK683699

DRUGINFO

ELTANOLONE

DRUGINFO

U-78875

DRUGINFO

CGS-17867A

DRUGINFO

CGS-9896

DRUGINFO

(2E,4S)-4-ammoniopent-2-enoate