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靶点信息18(本栏目收费,不能显示细节,电话15274084725)
靶点信息
TARGNAME
HLA-DR antigens-associated invariant (CD74)
TARGTYPE
Clinical trial target
SYNONYMS
Ii; Ia antigenassociated invariant chain; Ia antigen-associated invariant chain; HLADR antigensassociated invariant chain; HLA-DR antigens-associated invariant chain; HLA class II histocompatibility antigen gamma chain; DHLAG
FUNCTION
Serves as cell surface receptor for the cytokine MIF. Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place.
PDBSTRUC
5KSV; 5KSU; 4X5W; 4AH2; 4AEN
SEQUENCE
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
KEGGPATH
hsa04612:Antigen processing and presentation
KEGGPATH
hsa05152:Tuberculosis
KEGGPATH
hsa05168:Herpes simplex infection
WIKIPATH
WP2679:MHC class II antigen presentation
REACPATH
R-HSA-2132295:MHC class II antigen presentation
NET_PATH
NetPath_23:TSH Signaling Pathway
PANTPATH
P00053:T cell activation
目标的 KEGG 通路数据
标题 | 内容 |
hsa04612 |
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hsa05152 |
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hsa05168 |
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目标的蛋白质ID
标题 | 内容 |
TARGETID |
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UNIPROID |
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TARGNAME |
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TARGTYPE |
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目标的序列数据
标题 | 内容 |
HLA-DR antigens-associated invariant (CD74) |
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