TARGETID

T07400

FORMERID

TTDR00745

UNIPROID

RAGE_HUMAN

TARGNAME

Advanced glycosylation end product receptor (AGER)

GENENAME

AGER

TARGTYPE

Clinical trial target

SYNONYMS

Receptor foradvanced glycosylation end products; RAGESEC; RAGE; AGER

FUNCTION

Mediates interactions of advanced glycosylation end products (age). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.

PDBSTRUC

5D7F; 4YBH; 4XYN; 4P2Y; 4OI8

BIOCLASS

Immunoglobulin

SEQUENCE

MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP

DRUGINFO

PF-4494700

DRUGINFO

Pyridoxamine

DRUGINFO

Alagebrium chloride

DRUGINFO

TTP-448

DRUGINFO

TTP-4000

DRUGINFO

DBT-066

WIKIPATH

WP1781:Advanced glycosylation endproduct receptor signaling

WIKIPATH

WP1904:RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

WIKIPATH

WP2324:AGE/RAGE pathway