TARGETID

T07279

FORMERID

TTDNR00746

UNIPROID

PIM2_HUMAN

TARGNAME

Serine/threonine-protein kinase pim-2 (PIM2)

GENENAME

PIM2

TARGTYPE

Clinical trial target

SYNONYMS

Pim-2h; PIM2

FUNCTION

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti- apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Isoform 1 is less active in this respect. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

PDBSTRUC

4X7Q; 2IWI

BIOCLASS

Kinase

ECNUMBER

EC 2.7.11.1

SEQUENCE

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP

DRUGINFO

LGH-447

DRUGINFO

AZD1208

DRUGINFO

IDDBCP226234

DRUGINFO

PMID21982499C14k

KEGGPATH

hsa05221:Acute myeloid leukemia

WIKIPATH

WP2849:Hematopoietic Stem Cell Differentiation

NET_PATH

NetPath_11:TCR Signaling Pathway

NET_PATH

NetPath_13:IL1 Signaling Pathway