TARGETID

T06955

FORMERID

TTDC00226

UNIPROID

CCR4_HUMAN

TARGNAME

C-C chemokine receptor type 4 (CCR4)

GENENAME

CCR4

TARGTYPE

Successful target

SYNONYMS

K5-5; CMKBR4; CD194; CCR-4; CC-CKR-4; CC chemokine receptor 4; C-CCKR-4; C-C CKR-4

FUNCTION

The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

DRUGINFO

Mogamulizumab

DRUGINFO

FLX475

DRUGINFO

ATLCAR.CD30.CCR4 cells

DRUGINFO

GSK-2239633

DRUGINFO

AZD-1678

DRUGINFO

4-isopropyl-N-(naphthalen-1-yl)thiazol-2-amine

DRUGINFO

4-methyl-N-(naphthalen-1-yl)thiazol-2-amine

DRUGINFO

4-tert-butyl-N-(2-isopropylphenyl)thiazol-2-amine

DRUGINFO

4-tert-butyl-N-(naphthalen-1-yl)oxazol-2-amine

DRUGINFO

4-tert-butyl-N-(naphthalen-1-yl)thiazol-2-amine