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靶点信息15(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cytokine ML-1 (IL17F)
TARGTYPE
Clinical trial target
SYNONYMS
Interleukin-17F; IL-17F
FUNCTION
The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. Ligand for IL17RA and IL17RC.
PDBSTRUC
5NAN; 5N92; 3JVF; 1JPY
BIOCLASS
Cytokine: interleukin
SEQUENCE
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04657:IL-17 signaling pathway
KEGGPATH
hsa04659:Th17 cell differentiation
KEGGPATH
hsa05321:Inflammatory bowel disease (IBD)
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04657 |
|
| hsa04659 |
|
| hsa05321 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Cytokine ML-1 (IL17F) |
|