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靶点信息24(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGTYPE
Clinical trial target
FUNCTION
It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Nucleolin is the major nucleolar protein of growing eukaryotic cells.
PDBSTRUC
2KRR; 2FC9; 2FC8
SEQUENCE
MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
WIKIPATH
WP2002:miR-targeted genes in epithelium - TarBase
WIKIPATH
WP2004:miR-targeted genes in lymphocytes - TarBase
WIKIPATH
WP2005:miR-targeted genes in muscle cell - TarBase
WIKIPATH
WP2006:miR-targeted genes in squamous cell - TarBase
WIKIPATH
WP2272:Pathogenic Escherichia coli infection
NET_PATH
NetPath_11:TCR Signaling Pathway
NET_PATH
NetPath_14:IL2 Signaling Pathway
目标的 Wiki 路径数据
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| WP2272 |
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| WP2006 |
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| WP2005 |
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| WP2004 |
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| WP2002 |
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目标的蛋白质ID
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