TARGETID

T06182

FORMERID

TTDI02208

UNIPROID

VIPR2_HUMAN

TARGNAME

Helodermin-preferring VIP receptor (VIPR2)

GENENAME

VIPR2

TARGTYPE

Clinical trial target

SYNONYMS

Vasoactive intestinal polypeptide receptor 2; VPAC2; VIPR2; VIP-R-2; Pituitary adenylate cyclase-activating polypeptide typeIII receptor; PACAP-R3; PACAP-R-3; PACAP type III receptor

FUNCTION

This is a receptor for VIP as well as PACAP-38 and -27,the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C.

PDBSTRUC

2X57

BIOCLASS

GPCR secretin

SEQUENCE

MRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI

DRUGINFO

PB1046

DRUGINFO

RG-7103

DRUGINFO

helodermin

DRUGINFO

PACAP-27

DRUGINFO

PB-1120

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04080:Neuroactive ligand-receptor interaction

WIKIPATH

WP1824:GPCR downstream signaling

WIKIPATH

WP1825:GPCR ligand binding