TARGETID

T05880

UNIPROID

APH1A_HUMAN-APH1B_HUMAN

TARGNAME

Gamma-secretase subunit APH-1A/1B (APH-1)

GENENAME

APH1A-APH1B

TARGTYPE

Patented-recorded target

SYNONYMS

Anterior pharynx-defective 1

FUNCTION

The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

SEQUENCE

MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSRMGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED

DRUGINFO

PMID28350212-Compound-1

DRUGINFO

PMID28350212-Compound-12

DRUGINFO

PMID28350212-Compound-13

DRUGINFO

PMID28350212-Compound-15

DRUGINFO

PMID28350212-Compound-16

DRUGINFO

PMID28350212-Compound-18

DRUGINFO

PMID28350212-Compound-19

DRUGINFO

PMID28350212-Compound-20

DRUGINFO

PMID28350212-Compound-21

DRUGINFO

PMID28350212-Compound-22

DRUGINFO

PMID28350212-Compound-23

DRUGINFO

PMID28350212-Compound-24