TARGETID

T05849

FORMERID

TTDS00043

UNIPROID

GASR_HUMAN

TARGNAME

Gastrin/cholecystokinin type B receptor (CCKBR)

GENENAME

CCKBR

TARGTYPE

Successful target

SYNONYMS

Cholecystokinin-2 receptor; CCKRB; CCK2-R; CCK-BR; CCK-B receptor

FUNCTION

The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Receptor for gastrin and cholecystokinin.

PDBSTRUC

1L4T

BIOCLASS

GPCR rhodopsin

SEQUENCE

MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG

DRUGINFO

Ceruletide

DRUGINFO

Pentagastrin

DRUGINFO

GASTRAZOLE

DRUGINFO

Dexloxiglumide

DRUGINFO

Itriglumide

DRUGINFO

S-0509

DRUGINFO

Spiroglumide

DRUGINFO

TT-223

DRUGINFO

YF-476