TARGETID

T05387

FORMERID

TTDC00120

UNIPROID

TGM2_HUMAN

TARGNAME

Tissue transglutaminase (TG2)

GENENAME

TGM2

TARGTYPE

Preclinical target

SYNONYMS

Transglutaminase-2; Transglutaminase H; Transglutaminase C; Transglutaminase 2; Tranglutaminase 2; TTg; TGase-H; TGase-2; TGase H; TGase C; TGC; TG(C)Protein-glutamine gamma-glutamyltransferase; TG(C); Protein-glutamine gamma-glutamyltransferase 2

FUNCTION

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

PDBSTRUC

6A8P; 4PYG; 3S3S; 3S3P; 3S3J

BIOCLASS

Acyltransferase

ECNUMBER

EC 2.3.2.13

SEQUENCE

MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA

DRUGINFO

2-alkyloxy-3-phenylethynyl-4a,5-dihydropyrido[2,3-b]pyrazine derivative 1

DRUGINFO

3-acylidene-2-oxoindole derivative 1

DRUGINFO

3-acylidene-2-oxoindole derivative 2

DRUGINFO

Acyl piperidine derivative 2

DRUGINFO

Acyl piperidine derivative 3

DRUGINFO

Azachalcone derivative 1

DRUGINFO

Benzotriazole derivative 1

DRUGINFO

Chalcone derivative 5