靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T04507

FORMERID

TTDR00806

UNIPROID

DLG4_HUMAN

TARGNAME

Presynaptic density protein 95 (DLG4)

GENENAME

DLG4

TARGTYPE

Clinical trial target

SYNONYMS

Synapse-associated protein 90; SAP90; SAP-90; Postsynaptic density-95; Postsynaptic density protein 95; PSD95; PSD-95; Disks large homolog 4; Discs, large homolog 4

FUNCTION

Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels.

PDBSTRUC

6QJN; 6QJL; 6QJK; 6QJJ; 6QJI

BIOCLASS

Ezrin/radixin/moesin-binding phosphoprotein 50

SEQUENCE

MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL

DRUGINFO

D01JLO

Tat-NR2B9c

Phase 3

DRUGINFO

D06GOK

2-Methyl-2,4-Pentanediol

DRUGINFO

FETAV

DRUGINFO

Guanosine-5'-Monophosphate

DRUGINFO

KSG-LDTKNYKQTSV

DRUGINFO

KSG-YEKLSSIESDV

DRUGINFO

N-(3,4-Dichlorophenyl)propyl-ETAV

Investigative

DRUGINFO

D00YVJ

N-(3,4-Difluorophenyl)propyl-ETAV

Investigative

DRUGINFO

D0T2HN

N-(Naphthalene-2-yl)ethyl-ETAV

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04390	Hippo signaling pathway
hsa04724	Glutamatergic synapse
hsa05016	Huntington's disease
hsa05030	Cocaine addiction

目标的 Wiki 路径数据

标题	内容
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP1843	L1CAM interactions

目标的蛋白质ID

标题	内容
TARGETID	T04507
UNIPROID	DLG4_HUMAN
TARGNAME	Presynaptic density protein 95 (DLG4)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Presynaptic density protein 95 (DLG4)	MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL

标题

内容

Presynaptic density protein 95 (DLG4)

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