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靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Staphylococcus Alpha-hemolysin (Stap-coc hly)
TARGTYPE
Clinical trial target
SYNONYMS
hla; Alpha-toxin; Alpha-hemolysin; Alpha-HL
FUNCTION
Alpha-toxin binds to the membrane of eukaryotic cells (particularly red blood cells, RBC) forming pores, resulting in hemolysis, with the release of low-molecular weight molecules leading to eventual osmotic RBC lysis. Human RBCs bind much less alpha-toxin than do rabbit RBCs. Heptamer oligomerization and pore formation is required for lytic activity.
PDBSTRUC
7AHL; 4YHD; 4IDJ; 3M4E; 3M4D
BIOCLASS
Alpha-hemolysin channel-forming toxin
SEQUENCE
MKTRIVSSVTTTLLLGSILMNPVAGAADSDINIKTGTTDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
WIKIPATH
WP2763:Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACPATH
R-HSA-844456:The NLRP3 inflammasome
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Staphylococcus Alpha-hemolysin (Stap-coc hly) |
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