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靶点信息

标题

内容

相关药物

状态

TARGETID

T03755

FORMERID

TTDC00244

UNIPROID

B2CL2_HUMAN

TARGNAME

Apoptosis regulator Bcl-W (BCL-W)

GENENAME

BCL2L2

TARGTYPE

Clinical trial target

SYNONYMS

KIAA0271; Bcl2-L-2; Bcl-2-like protein 2; BCLW

FUNCTION

Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Promotes cell survival.

PDBSTRUC

4CIM; 2Y6W; 1ZY3; 1O0L; 1MK3

BIOCLASS

B-cell lymphoma Bcl-2

SEQUENCE

MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

DRUGINFO

D06ETI

ABT-263

Phase 3

DRUGINFO

D0TU3N

PMID27744724-Compound-18

Patented

KEGGPATH

hsa05206:MicroRNAs in cancer

WIKIPATH

WP1772:Apoptosis Modulation and Signaling

WIKIPATH

WP254:Apoptosis

INTEPATH

p53downstreampathway:Direct p53 effectors

PANTPATH

P00006:Apoptosis signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa05206	MicroRNAs in cancer

目标的 Wiki 路径数据

标题	内容
WP254	Apoptosis
WP1772	Apoptosis Modulation and Signaling

目标的蛋白质ID

标题	内容
TARGETID	T03755
UNIPROID	B2CL2_HUMAN
TARGNAME	Apoptosis regulator Bcl-W (BCL-W)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Apoptosis regulator Bcl-W (BCL-W)	MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK

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