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靶点信息83(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Leukotriene A-4 hydrolase (LTA4H)
TARGTYPE
Successful target
SYNONYMS
Leukotriene A4 hydrolase; Leukotriene A(4)Leukotriene A-4 hydrolase hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA-H; LTA-4hydrolase; LTA-4 hydrolase
FUNCTION
Has also aminopeptidase activity. Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4.
PDBSTRUC
6END; 6ENC; 6ENB; 5NIE; 5NID
BIOCLASS
Ether bond hydrolase
SEQUENCE
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
DRUGINFO
(4-(thiophen-2-yl)phenyl)methanamine
DRUGINFO
(4-fluorophenyl)(pyridin-4-yl)methanone
DRUGINFO
(R)-2-((4-benzylphenoxy)methyl)piperidine
DRUGINFO
(R)-2-((4-phenoxyphenoxy)methyl)piperidine
DRUGINFO
(R)-2-(4-Benzylphenoxymethyl)pyrrolidine
目标的蛋白质ID
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| UNIPROID |
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| TARGNAME |
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目标的序列数据
| 标题 | 内容 |
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| Leukotriene A-4 hydrolase (LTA4H) |
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