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靶点信息28(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Synuclein alpha (SNCA)
TARGTYPE
Clinical trial target
SYNONYMS
PARK1; Non-A4 component of amyloid precursor; Non-A beta component of AD amyloid; NACP; Alpha-synuclein
FUNCTION
Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
PDBSTRUC
6H6B; 6FLT; 6CU8; 6CU7; 6CT7
SEQUENCE
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
DRUGINFO
Posiphen R-phenserine
KEGGPATH
hsa05010:Alzheimer's disease
KEGGPATH
hsa05012:Parkinson's disease
WIKIPATH
WP2059:Alzheimers Disease
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP2858 |
|
| WP2371 |
|
| WP2359 |
|
| WP2059 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Synuclein alpha (SNCA) |
|