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靶点信息62(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Matrix metalloproteinase-12 (MMP-12)
TARGTYPE
Clinical trial target
SYNONYMS
Macrophage metalloelastase; Macrophage elastase; MME; ME; HME
FUNCTION
Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. May be involved in tissue injury and remodeling.
PDBSTRUC
6EOX; 6ENM; 6ELA; 6EKN; 5N5K
SEQUENCE
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
DRUGINFO
PMID29130358-Compound-Figure17(10)
DRUGINFO
PMID29130358-Compound-Figure17(11)
DRUGINFO
PMID29130358-Compound-Figure17(12)
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Matrix metalloproteinase-12 (MMP-12) |
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