TARGETID

T02728

FORMERID

TTDC00144

UNIPROID

NTR1_HUMAN

TARGNAME

Neurotensin receptor type 1 (NTSR1)

GENENAME

NTSR1

TARGTYPE

Clinical trial target

SYNONYMS

NTSR1; NTRH; NTR1; NTR subtype 1; NT-R1; NT-R-1; High-affinity levocabastine-insensitive neurotensin receptor

FUNCTION

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

PDBSTRUC

2LYW

BIOCLASS

GPCR rhodopsin

SEQUENCE

MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY

DRUGINFO

Meclinertant

DRUGINFO

ABS-212

DRUGINFO

CGX-1160

DRUGINFO

[3H]meclinertant

DRUGINFO

4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one

DRUGINFO

Demotensin 1

DRUGINFO

Demotensin 2

DRUGINFO

Demotensin 3

DRUGINFO

Demotensin 4