TARGETID

T02677

FORMERID

TTDC00273

UNIPROID

BIRC5_HUMAN

TARGNAME

Apoptosis inhibitor survivin (BIRC5)

GENENAME

BIRC5

TARGTYPE

Clinical trial target

SYNONYMS

Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; API4

FUNCTION

Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis.

PDBSTRUC

4A0N; 4A0J; 4A0I; 3UIK; 3UIJ

BIOCLASS

Acyltransferase

SEQUENCE

MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD

DRUGINFO

ISIS 23722

DRUGINFO

SurVaxM

DRUGINFO

CV-9201

DRUGINFO

EZN-3042

KEGGPATH

hsa04390:Hippo signaling pathway

KEGGPATH

hsa05161:Hepatitis B

KEGGPATH

hsa05200:Pathways in cancer

KEGGPATH

hsa05210:Colorectal cancer

WIKIPATH

WP1772:Apoptosis Modulation and Signaling