TARGETID

T02617

FORMERID

TTDI02373

UNIPROID

TRFE_HUMAN

TARGNAME

Transferrin (TF)

GENENAME

TF

TARGTYPE

Clinical trial target

SYNONYMS

Siderophilin; Serotransferrin; PRO1400; Beta-1 metal-binding globulin

FUNCTION

It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.

PDBSTRUC

6D05; 6D04; 6D03; 6CTC; 5Y6K

BIOCLASS

Transferrin

SEQUENCE

MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP

DRUGINFO

CALAA-01

DRUGINFO

EP-2167

KEGGPATH

hsa04066:HIF-1 signaling pathway

KEGGPATH

hsa04978:Mineral absorption

WIKIPATH

WP2007:Iron metabolism in placenta

WIKIPATH

WP2670:Iron uptake and transport

WIKIPATH

WP2848:Differentiation Pathway

WIKIPATH

WP706:SIDS Susceptibility Pathways

REACPATH

R-HSA-114608:Platelet degranulation