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靶点信息

标题

内容

相关药物

状态

TARGETID

T02551

FORMERID

TTDS00013

UNIPROID

DRD3_HUMAN

TARGNAME

Dopamine D3 receptor (D3R)

GENENAME

DRD3

TARGTYPE

Successful target

SYNONYMS

D(3) dopamine receptor

FUNCTION

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.

PDBSTRUC

3PBL

BIOCLASS

GPCR rhodopsin

SEQUENCE

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

DRUGINFO

Cariprazine

DRUGINFO

Pramipexole

DRUGINFO

Ropinirole

DRUGINFO

CM-2395

DRUGINFO

P2B-001

DRUGINFO

GSK598809

DRUGINFO

ONC201

DRUGINFO

RP5063

DRUGINFO

TAK-906

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction
hsa04728	Dopaminergic synapse

目标的 Wiki 路径数据

标题	内容
WP58	Monoamine GPCRs
WP455	GPCRs, Class A Rhodopsin-like
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP1602	Nicotine Activity on Dopaminergic Neurons
WP117	GPCRs, Other

目标的蛋白质ID

标题	内容
TARGETID	T02551
UNIPROID	DRD3_HUMAN
TARGNAME	Dopamine D3 receptor (D3R)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Dopamine D3 receptor (D3R)	MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

标题

内容

Dopamine D3 receptor (D3R)

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