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靶点信息27(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
B-cell-activating factor (TNFSF13B)
TARGTYPE
Successful target
SYNONYMS
ZTNF4; UNQ401/PRO738; Tumor necrosis factor ligand superfamily member 13B; TNFSF20; TNF-and APOL-related leukocyte expressed ligand 1; TNF- and APOL-related leukocyte expressed ligand 1; TALL1; TALL-1; Dendritic cell-derived TNF-like molecule; CD257; BLyS; BAFF; B lymphocyte stimulator; B cell-activating factor
FUNCTION
TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA.
PDBSTRUC
6FXN; 5Y9J; 4ZCH; 4V46; 3V56
BIOCLASS
Cytokine: tumor necrosis factor
SEQUENCE
MDDSTEREQSRLTSCLKKREEMKLKECVSILPRKESPSVRSSKDGKLLAATLLLALLSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAGAPKAGLEEAPAVTAGLKIFEPPAPGEGNSSQNSRNKRAVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL
DRUGINFO
1,4-Diethylene Dioxide
DRUGINFO
Receptor-Fc fusion proteins
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04064 |
|
| hsa04672 |
|
| hsa05323 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| B-cell-activating factor (TNFSF13B) |
|