靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T01597

FORMERID

TTDI02035

UNIPROID

CATA_HUMAN

TARGNAME

Catalase (CAT)

GENENAME

CAT

TARGTYPE

Clinical trial target

SYNONYMS

Human catalase

FUNCTION

Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

PDBSTRUC

1QQW; 1F4J; 1DGH; 1DGG; 1DGF

BIOCLASS

Peroxide acceptor oxidoreductase

ECNUMBER

EC 1.11.1.6

SEQUENCE

MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

DRUGINFO

D06VAQ

EUK-189

Phase 1

KEGGPATH

hsa00380:Tryptophan metabolism

KEGGPATH

hsa00630:Glyoxylate and dicarboxylate metabolism

KEGGPATH

hsa01130:Biosynthesis of antibiotics

KEGGPATH

hsa04068:FoxO signaling pathway

KEGGPATH

hsa04146:Peroxisome

KEGGPATH

hsa05014:Amyotrophic lateral sclerosis (ALS)

WIKIPATH

WP15:Selenium Micronutrient Network

目标的 KEGG 通路数据

标题	内容
hsa00380	Tryptophan metabolism
hsa00630	Glyoxylate and dicarboxylate metabolism
hsa01130	Biosynthesis of antibiotics
hsa04068	FoxO signaling pathway
hsa04146	Peroxisome
hsa05014	Amyotrophic lateral sclerosis (ALS)

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP465	Tryptophan metabolism
WP408	Oxidative Stress
WP2824	Detoxification of Reactive Oxygen Species
WP2447	Amyotrophic lateral sclerosis (ALS)
WP1851	Metabolism of nucleotides
WP176	Folate Metabolism
WP15	Selenium Micronutrient Network

目标的蛋白质ID

标题	内容
TARGETID	T01597
UNIPROID	CATA_HUMAN
TARGNAME	Catalase (CAT)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Catalase (CAT)	MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

标题

内容

Catalase (CAT)

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