TARGETID

T01575

FORMERID

TTDI02173

UNIPROID

SGPL1_HUMAN

TARGNAME

Sphingosine-1-phosphate lyase 1 (SGPL1)

GENENAME

SGPL1

TARGTYPE

Clinical trial target

SYNONYMS

hSPL; Sphingosine-1-phosphate aldolase; SPL 1; SP-lyase 1; S1PL; KIAA1252

FUNCTION

Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine.

PDBSTRUC

4Q6R

BIOCLASS

Carbon-carbon lyase

ECNUMBER

EC 4.1.2.27

SEQUENCE

MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH

DRUGINFO

LX2931

DRUGINFO

LX-2932

DRUGINFO

PMID24809814C31

KEGGPATH

hsa00600:Sphingolipid metabolism

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa04071:Sphingolipid signaling pathway

WIKIPATH

WP2788:Sphingolipid metabolism

WHIZPATH

PW000148:Sphingolipid Metabolism