TARGETID

T01283

FORMERID

TTDI02200

UNIPROID

TS101_HUMAN

TARGNAME

Tumor susceptibility gene protein 101 (TSG101)

GENENAME

TSG101

TARGTYPE

Clinical trial target

SYNONYMS

Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101

FUNCTION

Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan. It may also play a role in the extracellular release of microvesicles that differ from the exosomes. Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

PDBSTRUC

5VKG; 4ZNY; 4YC1; 4EJE; 3P9H

BIOCLASS

Ubiquitin-conjugating enzyme

SEQUENCE

MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY

DRUGINFO

FGI-101-1A6

KEGGPATH

hsa04144:Endocytosis

WIKIPATH

WP1846:Membrane Trafficking

WIKIPATH

WP2658:HIV Life Cycle

REACPATH

R-HSA-162588:Budding and maturation of HIV virion

REACPATH

R-HSA-174490:Membrane binding and targetting of GAG proteins

INTEPATH

erbb1_internalization_pathway:Internalization of ErbB1

INTEPATH

reg_gr_pathway:Glucocorticoid receptor regulatory network