当前位置：药药网 / 数据中心 /靶点信息(本栏目收费,不能显示细节,电话13136136841)
靶点信息45(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
C-X-C chemokine receptor type 1 (CXCR1)
TARGTYPE
Successful target
SYNONYMS
Interleukin-8 receptor A; IL8RA; IL-8R A; IL-8 receptor type 1; High affinity interleukin-8 receptor A; CXCR-1; CXC-R1; CMKAR1; CDw128a; CD181
FUNCTION
Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor.
PDBSTRUC
2LNL; 1ILQ; 1ILP
SEQUENCE
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
DRUGINFO
(R)-2-(4-Isobutyl-phenyl)-N-methoxy-propionamide
DRUGINFO
(R)-2-(4-Isobutyl-phenyl)-propionamide
DRUGINFO
(R)-3-(4-Isobutyl-phenyl)-butan-2-one
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04062 |
|
| hsa04144 |
|
| hsa05120 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP455 |
|
| WP2848 |
|
| WP24 |
|
| WP1825 |
|
| WP1824 |
|
| WP117 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| C-X-C chemokine receptor type 1 (CXCR1) |
|