TARGETID

T00484

FORMERID

TTDI02336

UNIPROID

IL23R_HUMAN

TARGNAME

Interleukin 23 receptor (IL23R)

GENENAME

IL23R

TARGTYPE

Clinical trial target

SYNONYMS

Interleukin-23 receptor; IL23 receptor; IL-23R; IL-23 receptor

FUNCTION

Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Associates with IL12RB1 to form the interleukin-23 receptor.

PDBSTRUC

5MZV

BIOCLASS

Cytokine receptor

SEQUENCE

MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK

DRUGINFO

Anti-IL-23

DRUGINFO

ADC-1012

DRUGINFO

APG-2305

DRUGINFO

FM-303

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04630:Jak-STAT signaling pathway

KEGGPATH

hsa05321:Inflammatory bowel disease (IBD)

INTEPATH

il23pathway:IL23-mediated signaling events