靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T99909

FORMERID

TTDI02086

UNIPROID

GRP75_HUMAN

TARGNAME

Mortalin (HSPA9)

GENENAME

HSPA9

TARGTYPE

Clinical trial target

SYNONYMS

mt-HSP70; Stress-70 protein, mitochondrial; Peptide-binding protein 74; PBP74; MOT; Heat shock 70 kDa protein 9; HSPA9B; GRP75; GRP-75; 75 kDa glucose-regulated protein

FUNCTION

Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis.

PDBSTRUC

6NHK; 4KBO; 3N8E

BIOCLASS

Heat shock protein

SEQUENCE

MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ

DRUGINFO

D0X9HB

MKT-077

Phase 2

KEGGPATH

hsa03018:RNA degradation

KEGGPATH

hsa05152:Tuberculosis

WIKIPATH

WP2359:Parkin-Ubiquitin Proteasomal System pathway

WIKIPATH

WP2717:Mitochondrial Protein Import

REACPATH

R-HSA-1268020:Mitochondrial protein import

REACPATH

R-HSA-3371453:Regulation of HSF1-mediated heat shock response

NET_PATH

NetPath_11:TCR Signaling Pathway

NET_PATH

NetPath_23:TSH Signaling Pathway

目标的 KEGG 通路数据

标题	内容
hsa03018	RNA degradation
hsa05152	Tuberculosis

目标的 Wiki 路径数据

标题	内容
WP2717	Mitochondrial Protein Import
WP2359	Parkin-Ubiquitin Proteasomal System pathway

目标的蛋白质ID

标题	内容
TARGETID	T99909
UNIPROID	GRP75_HUMAN
TARGNAME	Mortalin (HSPA9)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Mortalin (HSPA9)	MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ

标题

内容

Mortalin (HSPA9)

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