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靶点信息60(本栏目收费,不能显示细节,电话13136136841)
靶点信息
UNIPROID
APH1A_HUMAN; APH1B_HUMAN; PEN2_HUMAN; NICA_HUMAN; PSN1_HUMAN
TARGNAME
Gamma-secretase (GS)
GENENAME
APH1A; APH1B; NCSTN; PSENEN; PSEN1
TARGTYPE
Clinical trial target
SYNONYMS
Presenilin-stabilization factor-like; PSFL; Aph-1beta
FUNCTION
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
SEQUENCE
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCRRQEDSRVMVYSALRIPPED
DRUGINFO
(S)-FLURBIPROFEN
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP61 |
|
| WP2781 |
|
| WP2722 |
|
| WP2721 |
|
| WP2720 |
|
| WP2718 |
|
| WP268 |
|
| WP1976 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Gamma-secretase (GS) |
|