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靶点信息50(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Gastrin-releasing peptide receptor (GRPR)
TARGTYPE
Clinical trial target
SYNONYMS
GRPR; GRP-preferring bombesin receptor; GRP-R; Bombesin/gastrin-releasing peptide receptor
FUNCTION
Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
SEQUENCE
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
DRUGINFO
177Lu-labelled NeoBOMB1
DRUGINFO
(CH3)CCO-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2
DRUGINFO
(D)Phe-Gln-Trp-Ala-Val-Gly-His-Leu-Leu-NH2
DRUGINFO
[(N4-Bzdig)0,Nle14]BB(7-14)
DRUGINFO
[(N4-Bzdig)0]BB(7-14)
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Gastrin-releasing peptide receptor (GRPR) |
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