TARGETID

T99765

FORMERID

TTDI01737

UNIPROID

SUMO1_HUMAN; SUMO2_HUMAN; SUMO3_HUMAN; SUMO4_HUMAN; SUMO5_HUMAN

TARGNAME

Small ubiquitin-related modifier (SUMO)

GENENAME

SUMO1; SUMO2; SUMO3; SUMO4; SUMO1P1

TARGTYPE

Preclinical target

SYNONYMS

Ubiquitin-like protein; SUMO; SMT3 homolog 1

FUNCTION

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.

SEQUENCE

MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV

DRUGINFO

2-D08