靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

WIKIPATH

WP554:ACE Inhibitor Pathway

WIKIPATH

WP560:TGF Beta Signaling Pathway

WIKIPATH

WP615:Senescence and Autophagy in Cancer

WIKIPATH

WP69:TCR Signaling Pathway

WIKIPATH

WP710:DNA Damage Response (only ATM dependent)

REACPATH

R-HSA-114608:Platelet degranulation

REACPATH

R-HSA-2129379:Molecules associated with elastic fibres

REACPATH

R-HSA-2173789:TGF-beta receptor signaling activates SMADs

REACPATH

R-HSA-2173791:TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

REACPATH

R-HSA-3000170:Syndecan interactions

REACPATH

R-HSA-3000178:ECM proteoglycans

REACPATH

R-HSA-3304356:SMAD2/3 Phosphorylation Motif Mutants in Cancer

REACPATH

R-HSA-3315487:SMAD2/3 MH2 Domain Mutants in Cancer

REACPATH

R-HSA-3645790:TGFBR2 Kinase Domain Mutants in Cancer

REACPATH

R-HSA-3656532:TGFBR1 KD Mutants in Cancer

REACPATH

R-HSA-3656535:TGFBR1 LBD Mutants in Cancer

REACPATH

R-HSA-381340:Transcriptional regulation of white adipocyte differentiation

NET_PATH

NetPath_11:TCR Signaling Pathway

NET_PATH

NetPath_15:IL3 Signaling Pathway

NET_PATH

NetPath_7:TGF_beta_Receptor Signaling Pathway

目标的 KEGG 通路数据

标题	内容
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05144	Malaria
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05161	Hepatitis B
hsa05166	HTLV-I infection
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia
hsa05321	Inflammatory bowel disease (IBD)
hsa05323	Rheumatoid arthritis
hsa05410	Hypertrophic cardiomyopathy (HCM)
hsa05414	Dilated cardiomyopathy
hsa04010	MAPK signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04068	FoxO signaling pathway
hsa04110	Cell cycle
hsa04144	Endocytosis
hsa04350	TGF-beta signaling pathway
hsa04380	Osteoclast differentiation
hsa04390	Hippo signaling pathway
hsa04672	Intestinal immune network for IgA production

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP69	TCR Signaling Pathway
WP615	Senescence and Autophagy in Cancer
WP560	TGF Beta Signaling Pathway
WP554	ACE Inhibitor Pathway
WP530	Cytokines and Inflammatory Response
WP474	Endochondral Ossification
WP382	MAPK Signaling Pathway
WP366	TGF beta Signaling Pathway
WP2884	NRF2 pathway
WP2882	Nuclear Receptors Meta-Pathway
WP2877	Vitamin D Receptor Pathway
WP2873	Aryl Hydrocarbon Receptor Pathway
WP2870	Extracellular vesicle-mediated signaling in recipient cells
WP286	IL-3 Signaling Pathway
WP2855	Dopaminergic Neurogenesis
WP2853	Endoderm Differentiation
WP2849	Hematopoietic Stem Cell Differentiation
WP2848	Differentiation Pathway
WP2840	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
WP2795	Cardiac Hypertrophic Response
WP2787	Syndecan interactions
WP2771	Host Interactions with Influenza Factors
WP2751	Transcriptional Regulation of White Adipocyte Differentiation
WP2742	Signaling by TGF-beta Receptor Complex
WP2703	Extracellular matrix organization
WP2666	Elastic fibre formation
WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
WP2431	Spinal Cord Injury
WP2406	Cardiac Progenitor Differentiation
WP2377	Integrated Pancreatic Cancer Pathway
WP236	Adipogenesis
WP2355	Corticotropin-releasing hormone
WP2332	Interleukin-11 Signaling Pathway
WP2328	Allograft Rejection
WP179	Cell Cycle
WP1559	TFs Regulate miRNAs related to cardiac hypertrophy
WP1544	MicroRNAs in cardiomyocyte hypertrophy

目标的蛋白质ID

标题	内容
TARGETID	T97257
UNIPROID	TGFB1_HUMAN
TARGNAME	Transforming growth factor beta 1 (TGFB1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Transforming growth factor beta 1 (TGFB1)	MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

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