TARGETID

T95558

FORMERID

TTDS00531

UNIPROID

DGAT2_HUMAN

TARGNAME

Diacylglycerol O-acyltransferase 2 (DGAT2)

GENENAME

DGAT2

TARGTYPE

Successful target

SYNONYMS

UNQ738/PRO1433; HMFN1045; Diglyceride acyltransferase 2

FUNCTION

Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.

BIOCLASS

Acyltransferase

ECNUMBER

EC 2.3.1.20

SEQUENCE

MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN

DRUGINFO

Vitamin B3

DRUGINFO

ARI-3037MO

DRUGINFO

PF-06427878

DRUGINFO

PMID25470667-Compound-Figure4-1A

DRUGINFO

PMID25470667-Compound-roselipins

KEGGPATH

hsa00561:Glycerolipid metabolism

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa04975:Fat digestion and absorption

WIKIPATH

WP1817:Fatty acid, triacylglycerol, and ketone body metabolism