TARGETID

T95400

FORMERID

TTDS00484

UNIPROID

FCERG_HUMAN

TARGNAME

Immunoglobulin epsilon Fc receptor gamma (FCERG)

GENENAME

FCER1G

TARGTYPE

Successful target

SYNONYMS

IgE Fc receptor subunit gamma; High affinity immunoglobulin epsilon receptor subunit gamma; FceRI gamma; FcRgamma; Fc receptor gamma-chain

FUNCTION

As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors.

BIOCLASS

Immunoglobulin

SEQUENCE

MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ

DRUGINFO

Benzylpenicilloyl Polylysine

DRUGINFO

Omalizumab

DRUGINFO

Alpha-D-Mannose

DRUGINFO

Fucose

KEGGPATH

hsa04071:Sphingolipid signaling pathway

KEGGPATH

hsa04664:Fc epsilon RI signaling pathway

KEGGPATH

hsa05310:Asthma

WIKIPATH

WP2759:Fc epsilon receptor (FCERI) signaling

WIKIPATH

WP2865:IL1 and megakaryotyces in obesity

WHIZPATH

PW000453:Fc Epsilon Receptor I Signaling in Mast Cells