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靶点信息
TARGNAME
Calcium-activated potassium channel KCa2 (KCNN)
TARGTYPE
Clinical trial target
FUNCTION
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blockedby apamin.
BIOCLASS
Voltage-gated ion channel