靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T93903

FORMERID

TTDR01006

UNIPROID

CASP9_HUMAN

TARGNAME

Caspase-9 (CASP9)

GENENAME

CASP9

TARGTYPE

Clinical trial target

SYNONYMS

MCH6; ICE-like apoptotic protease 6; ICE-LAP6; CASP-9; Apoptotic protease-activating factor 3; Apoptotic protease activating factor 3; Apoptotic protease Mch-6; APAF-3

FUNCTION

Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Involved in the activation cascade of caspases responsible for apoptosis execution.

PDBSTRUC

5WVE; 5WVC; 5JUY; 4RHW; 3YGS

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.22.62

SEQUENCE

MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS

DRUGINFO

D0J3SU

isatin sulfonamide 34

DRUGINFO

Glionitrin A

DRUGINFO

NVX-207

DRUGINFO

Z-LEHD-fmk

KEGGPATH

hsa04115:p53 signaling pathway

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04210:Apoptosis

KEGGPATH

hsa04370:VEGF signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa04115	p53 signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04210	Apoptosis
hsa04370	VEGF signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa05010	Alzheimer's disease
hsa05012	Parkinson's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease
hsa05134	Legionellosis
hsa05145	Toxoplasmosis
hsa05152	Tuberculosis
hsa05161	Hepatitis B
hsa05164	Influenza A
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05215	Prostate cancer
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer
hsa05416	Viral myocarditis

目标的 Wiki 路径数据

标题	内容
WP707	DNA Damage Response
WP384	Apoptosis Modulation by HSP70
WP314	FAS pathway and Stress induction of HSP regulation
WP2653	PIP3 activates AKT signaling
WP254	Apoptosis
WP2447	Amyotrophic lateral sclerosis (ALS)
WP2377	Integrated Pancreatic Cancer Pathway
WP2371	Parkinsons Disease Pathway
WP2355	Corticotropin-releasing hormone
WP2328	Allograft Rejection
WP2324	AGE/RAGE pathway
WP231	TNF alpha Signaling Pathway
WP2263	Prostate Cancer
WP2059	Alzheimers Disease
WP1984	Integrated Breast Cancer Pathway
WP1971	Integrated Cancer pathway
WP1896	Regulation of Apoptosis
WP1841	Intrinsic Pathway for Apoptosis
WP1772	Apoptosis Modulation and Signaling
WP1530	miRNA Regulation of DNA Damage Response
WP1433	NOD pathway

目标的蛋白质ID

标题	内容
TARGETID	T93903
UNIPROID	CASP9_HUMAN
TARGNAME	Caspase-9 (CASP9)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Caspase-9 (CASP9)	MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS

标题

内容

Caspase-9 (CASP9)

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