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靶点信息24(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Delta(24)-sterol reductase (DHCR24)
TARGTYPE
Literature-reported target
SYNONYMS
Seladin-1; Diminuto/dwarf1 homolog; DHCR24
FUNCTION
Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
BIOCLASS
CH-CH donor oxidoreductase
SEQUENCE
MEPAVSLAVCALLFLLWVRLKGLEFVLIHQRWVFVCLFLLPLSLIFDIYYYVRAWVVFKLSSAPRLHEQRVRDIQKQVREWKEQGSKTFMCTGRPGWLTVSLRVGKYKKTHKNIMINLMDILEVDTKKQIVRVEPLVTMGQVTALLTSIGWTLPVLPELDDLTVGGLIMGTGIESSSHKYGLFQHICTAYELVLADGSFVRCTPSENSDLFYAVPWSCGTLGFLVAAEIRIIPAKKYVKLRFEPVRGLEAICAKFTHESQRQENHFVEGLLYSLDEAVIMTGVMTDEAEPSKLNSIGNYYKPWFFKHVENYLKTNREGLEYIPLRHYYHRHTRSIFWELQDIIPFGNNPIFRYLFGWMVPPKISLLKLTQGETLRKLYEQHHVVQDMLVPMKCLQQALHTFQNDIHVYPIWLCPFILPSQPGLVHPKGNEAELYIDIGAYGEPRVKHFEARSCMRQLEKFVRSVHGFQMLYADCYMNREEFWEMFDGSLYHKLREKLGCQDAFPEVYDKICKAARH
DRUGINFO
Diazacholesterol
KEGGPATH
hsa00100:Steroid biosynthesis
KEGGPATH
hsa01100:Metabolic pathways
WIKIPATH
WP1795:Cholesterol biosynthesis
WIKIPATH
WP465:Tryptophan metabolism
WHIZPATH
PW000050:Steroid Biosynthesis
REACPATH
R-HSA-191273:Cholesterol biosynthesis
NET_PATH
NetPath_11:TCR Signaling Pathway
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Delta(24)-sterol reductase (DHCR24) |
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