靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T90782

FORMERID

TTDR00731

UNIPROID

P2RY6_HUMAN

TARGNAME

P2Y purinoceptor 6 (P2RY6)

GENENAME

P2RY6

TARGTYPE

Clinical trial target

SYNONYMS

P2Y6; P2RY6; Adenosine P2Y6 receptor

FUNCTION

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

PDBSTRUC

2B6R

BIOCLASS

GPCR rhodopsin

SEQUENCE

MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR

DRUGINFO

D0D4HO

GC021109

Phase 1

DRUGINFO

D0Z7FU

INS 316

Discontinued in Phase 3

DRUGINFO

2MeSATP

DRUGINFO

3-phenacyl-UDP

DRUGINFO

5BrUTP

DRUGINFO

adenosine diphosphate

DRUGINFO

INS48823

DRUGINFO

MRS2567

DRUGINFO

MRS2578

目标的 KEGG 通路数据

标题	内容
hsa04080	Neuroactive ligand-receptor interaction

目标的 Wiki 路径数据

标题	内容
WP80	Nucleotide GPCRs
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling

目标的蛋白质ID

标题	内容
TARGETID	T90782
UNIPROID	P2RY6_HUMAN
TARGNAME	P2Y purinoceptor 6 (P2RY6)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
P2Y purinoceptor 6 (P2RY6)	MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR

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